October 28, 2022

B-cell lymphoma is a large group of heterogenous disorders and comprises a majority of non-Hodgkin lymphomas. As a poor survival rate characterizes these aggressive lymphomas, early detection and treatment is vital. Fluorescence in situ hybridization (FISH) is a sensitive method to detect smaller genomic changes associated with various hematological malignancies and solid tumors. The high sensitivity of FISH analysis detects low-level clones and identifies prognostically and therapeutically important genetic abnormalities. This new in-house panel delivers prompt results and complements HNL Genomics offerings.


The non-Hodgkin lymphoma FISH panel detects IGH gene translocations or rearrangements involving the 14q32 locus. Included in this group are follicular lymphoma (FL), Burkitt Lymphoma (BL), and diffuse large B-cell lymphoma (DLBCL). The characteristic chromosome abnormality t(14;18) resulting in IGH/BCL2 fusion is seen in about 80% of FL and about 20-30% of DLBCL. A majority of patients with BL harbor the characteristic t(8;14), resulting in c-MYC/IGH fusion. BCL6 gene rearrangements are also associated with B-cell lymphoma. Cyclin D1 gene rearrangements, especially the t(11;14), distinguish mantle cell lymphoma (ML) from other lymphoproliferative disorders, hence are diagnostic for ML.


There are several advantages of FISH technology over routine chromosome analysis, including the ability of FISH technology to detect genomic abnormalities in non-viable and non-dividing tissues, rapid turnaround time, and increased resolution. However, FISH technology is complementary to routine chromosome analysis and cannot substitute routine chromosome analysis for the diagnosis of cancer.
Providers suspecting non-Hodgkin lymphoma can order this panel easily using the test code FPNHL. Our genetic testing experts are available to assist with any questions. The average turnaround time for our non-Hodgkin lymphoma FISH panel is 3-4 days. Results are available in EPIC.

Test Summary

  • Non-Hodgkin lymphoma FISH panel
  • Detects most common abnormalities related to Non-Hodgkins Lymphoma (NHL) by chromosome analysis and FISH testing.
  • Test Code FPNHL
  • Turnaround time: 3-4 days

Time matters to your patients. HNL Lab Medicine delivers patient results quickly and conveniently. Please take advantage of our newly available non-Hodgkin lymphoma FISH panel to provide superior patient care.

For questions or assistance, please call 877-402-4221. For technical questions related to this test, please ask for Technical Support between the hours of 8 a.m. to 4:30 p.m. For general inquiries, Customer Care is available to assist at any time.

Following are the probes included in the NHL panel.

The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. HNL Lab Medicine strongly recommends confirmation of CPT codes with third-party payors and/or the AMA. We assume no responsibility for billing errors due to reliance upon CPT codes provided by HNL Lab Medicine.


October 28, 2022

Non-Hodgkin Lymphoma FISH Panel Now Available

B-cell lymphoma is a large group of heterogenous disorders and comprises a majority of non-Hodgkin lymphomas.
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Genome sequencing is reading or decoding the complete genetic information i.e. “Genome” of an organism that is encrypted in the form of a very long string called DNA made up of 4 letters, A, T, G, and C. The genome of an organism essentially determines their physical characteristics and ...
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The Effect of Genetics on Individual Heart Health: Early Identification of FH Variations to Optimize Treatment

Test must be ordered by a Physician.

Familial hypercholesterolemia (FH) is a genetic disorder that is characterized by abnormally high blood levels of low-density lipoprotein (LDL) cholesterol, sometimes referred to as "bad cholesterol". This condition affects an estimated 1 in 250 people, and increases the likelihood of developing cardiovascular disease. In fact, FH is estimated to be the cause of 2-3% of heart attacks in individuals younger than age 60.

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