Progressive pseudorheumatoid arthropathy of childhood (PPAC) Print

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Gene
WISP3
MIM
208230
Clinical Description

Progressive pseudorheumatoid arthropathy of childhood

Progressive pseudorheumatoid arthropathy of childhood (PPAC; MIM 208230) is an autosomal recessively inherited arthropathy due to mutations in the WISP3 gene. The WISP3 gene codes for WNT1-inducible signaling pathway protein 3. PPAC is a progressive disorder with childhood onset. Fatigue, muscle weakness, waddling gait, bowed legs and joint stiffness may be early manifestations. It is eventually characterized by osteoarthritis, joint swelling, stiffness, enlarged epiphyses, joint space narrowing, contractures and pain. Acetabular irregularity, coxa vara and periarticular osteoporosis can also occur. This disorder should be discriminated from juvenile rheumatoid arthritis and spondyloepiphyseal dysplasia tarda

Available Tests
The following test(s) are available for Progressive pseudorheumatoid arthropathy of childhood (PPAC)
DNA Sequencing
Price: $830
CPT Codes: 83890 83898 83894 83904 83912
  1 8 8 10 1
Deletion / Duplication Analysis - High-Density Targeted Array

Explanation of pricing:
The First Gene price and CPT codes below are for the first gene tested by HDT Array on a particular specimen.  The Additional Gene(s) price and CPT codes are for any subsequent gene(s) tested by HDT Array on the same specimen.

First Gene:
Price: $1,190
CPT Codes: 83890 83892 83894 88386 83912
  1 2 1 4 1
Additional Gene(s):
Price: $590
CPT Codes: 83890 83892 83894 88386 83912
  NA NA NA 4 1
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