Avascular necrosis of femoral head, primary (ANFH)

Avascular necrosis of femoral head, primary

Avascular necrosis of the femoral head, primary (ANFH; MIM 608805) is a debilitating disease and a common cause of hip replacement surgery. Avascular necrosis has been attributed to numerous causes including radiation therapy, corticosteroid use, trauma, thrombosis, infection, sickle cell disease, Gaucher disease, systemic lupus erythematosus, hereditary thrombophilia, alcohol abuse and chronic pancreatitis. Recently, mutations in COL2A1 have been linked to familial avascular necrosis of the femoral head.